Benefits of Olive Oil
Ibuprofen-like activity in extra-virgin olive oil
Enzymes in an inflammation pathway are inhibited by oleocanthal, a component of olive oil
September 1, 2005, pp. 45-46
Gary K. Beauchamp, Russell S. J. Keast, Diane Morel, Jianming Lin, Jana Pika,
Qiang Han, Chi-Ho Lee, Amos B. Smith and Paul A. S. Breslin
Newly pressed extra-virgin olive oil contains oleocanthal - a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen.
We show here that this similar perception seems to be an indicator of a sharedpharmacological activity, with oleocanthal acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen.
Although structurally dissimilar, both these molecules inhibit the same cyclooxygenase enzymes in the prostaglandin-biosynthesis pathway.
THESE AUTHORS ALSO NOTE:
The agent in extra-virgin olive oil responsible for throat irritation is thought to be oleocanthal, with oleo- for olive, -canth- for sting, and -al for aldehydes.
These authors isolated oleocanthal from different premium olive oils andmeasured its intensity as a throat irritant. They found that irritation intensity was positively correlated with oleocanthal concentration.
These authors tested whether oleocanthal might mimic the pharmacological effects of ibuprofen, a potent modulator of inflammation and analgesia.
Ibuprofen is a inhibitor of the cyclooxygenase enzymes COX-1 and COX-2, "which catalyse steps in the biochemical inflammation pathways derived from arachidonic acid." We found that, like ibuprofen, oleocanthal caused dose-dependent inhibition of COX-1 and COX-2 activities.
"Our findings raise the possibility that long-term consumption of oleocanthal may help to protect against some diseases by virtue of its ibuprofen-like COXinhibiting activity."
"If 50 g of extra-virgin olive oil containing up to 200 g per ml oleocanthal is ingested per day, of which 60-90% is absorbed, then this corresponds to an intake of up to 9 mg [of oleocanthal] per day."
"This dose is relatively low, corresponding to about 10% of the ibuprofen dosage recommended for adult pain relief, but it is known that regular low doses of aspirin, another COX inhibitor, confer cardiovascular health benefits."
A Mediterranean diet, which is rich in olive oil, confers various health benefits, including a reduction in the risk of developing some cancer, of platelet aggregation in the blood, and reduced incidence of Alzheimer's disease. "Our discovery of COXinhibitory activity in a component of olive oil offers a possible mechanistic explanation for this link."
1) Newly pressed extra-virgin olive oil contains a chemical called oleocanthal.
2) Ibuprofen is an inhibitor of the cyclooxygenase enzymes COX-1 and COX-2, which catalyse steps in the biochemical inflammation pathways derived from arachidonic acid to pro-inflammatory prostaglandins [PGE2].
3) Oleocanthal, like ibuprofen, caused dose-dependent inhibition of COX-1 and COX-2 activities with reduced pro-inflammatory prostaglandin-biosynthesis [PGE2].
4) Long-term consumption of extra-virgin olive oil that contains oleocanthal may protect against some diseases by virtue of its COX-inhibiting activity, including a reduction in the risk of developing some cancer, increased cardiovascular health, reduction of platelet aggregation in the blood, and reduced incidence of Alzheimer's disease.
5) Oleocanthal in extra-virgin olive oil may be responsible for the various health benefits Mediterranean diet.